United advanced into the Semi Finals after repeating their 2-0 victory over Granada at Old Trafford
The Red Devils progress without needed the help of their aggregate effort unlike AS Roma who were let through on a aggregate merit.
The Italians shared spoils with Ajax on their home ground but managed to scale through on a 3-2 aggregate victory.
Roma are now faced with a task to demolish Manchester United if they are to advance into the final stage of the competition.
Ole Gunnar believes the side will come as a major test to his squad after revealing his fears for Edin Dzeko who had been impressive for the side.
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‘I’ve not really seen too much of them,’ Solskjaer said to BT Sport.
‘I know they’ve had two good games against Ajax where they defended well, as Italian teams always do.
‘They are an experienced team and we all know Dzeko. Any ball in the box is a dangerous one.
‘We are looking forward to it, we are in the semi now and it feels like a proper European tie.
‘Roma is a club with loads of traditional and history but we have done well against Italian teams before.’
The tie would see Henrikh Mkhitaryan and Chris Smalling returning to Old Trafford.